The Season 1 finale of Best Medicine aired on Fox on April 7th, 2026 with multiple cliffhangers, leaving viewers wondering whether the show would be returning for a sophomore season. The answer is, thankfully, yes: Best Medicine Season 2 has been confirmed by Fox, and will arrive in the fall of 2026.

Best Medicine is a medical dramedy starring Josh Charles as Dr. Martin Best, a heart surgeon who is notable for his lack of bedside manner and his hemophobia. (That's a fear of blood, for those wondering.) The series is based on the popular British series Doc Martin, which ran from 2004 through 2022. In addition to Charles, Best Medicine also stars Abigail Spencer as Louisa Gavin, Josh Segarra as Sheriff Mark Mylow Cree as Elaine Denton and Annie Potts as Aunt Sarah. All are expected to return for the show's second season, which will also resolve the question of what happens to Martin now that the medical board knows about his fear of blood. His love triangle cliffhanger with Louisa and Eden? That one might continue for awhile, but that's why audiences keep tuning in.

There's even more good news for fans of the show, as Fox upped the episode count for the show's second season from 12 to 14, in what could only be considered a vote of confidence from the network. (One well-earned: the first season was the only scripted show to grow in audience from its first to second episode in the 2025-2026 broadcast year.) 

Best Medicine Season 2 has been confirmed to be airing on Tuesdays at 9pm as part of Fox's 2026-2027 broadcast season. While Fox has yet to release an official date for the season premiere, based on historical evidence, Best Medicine Season 2 should begin in the last week of September 2026.

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